A joint daily pill mixed with a pain reliever could create a “triple punch” that could damage the kidneys, a study warns.
The organ damage could be permanent.
Ibuprofen is used to relieve the pain of a range of ailments, from menstrual cramps to headaches and back pain.
However, scientists warn that some people taking medication for high blood pressure should be careful.
Combining their daily pill with ibuprofen could put many people at risk without realizing it.
One in three Britons has high blood pressure (hypertension), around half of whom are diagnosed and prescribed pills.
Diuretics and renin-angiotensin system (RSA) inhibitors are among the treatments used.
RSAs are given to most people under the age of 55 with high blood pressure and include ACE inhibitors and ARBs.
Some people take a variety of medications to keep their blood pressure under control.
Researchers at the University of Waterloo, Canada, used a series of computer-simulated drug studies to model the interactions of these routinely prescribed drugs with ibuprofen.
They found that the combination could cause acute kidney injury, which in some cases could be permanent.
Professor Anita Layton, lead author of the study, said: “Diuretics are a family of drugs that cause the body to hold less water.
“Dehydration is a major factor in acute kidney injury, and that’s when the RAS inhibitor and ibuprofen hit the kidney with that triple whammy.”
Human clinical trials would confirm the computer’s conclusions.
Prof Layton said: ‘It’s not like anyone who happens to be taking this combination of drugs is going to have problems.
“But research shows it’s a problem enough that you should exercise caution.”
Prof Layton said if you’re on these drugs and need a pain reliever, take acetaminophen.
But it comes after another team of experts warned that taking acetaminophen daily increases the risk of a heart attack or stroke by 20 percent in patients with high blood pressure.
They said doctors should give the lowest possible dose for the shortest amount of time when people need it for pain control.
The NHS says people who are unable to control their blood pressure should tell their doctor if they plan to use ibuprofen.
It also says that those with kidney problems who want to take ibuprofen or acetaminophen should speak to an expert first.
Pregnant women, people with heart disease, asthma, allergies, Crohn’s disease or a stomach ulcer are also warned against taking ibuprofen.
The NHS also says ibuprofen, which falls under the group of nonsteroidal anti-inflammatory drugs (NSAIDs), could further increase blood pressure.
https://www.the-sun.com/health/5321671/mixing-ibuprofen-high-blood-pressure-pills-risks-kidney-damage/ Warning: Mixing pain relievers with common daily medication risks triple whammy kidney damage