A “GHOST heart” grown using a scaffold made from a pig organ and human cells could soon be used in human transplants, experts say.
One molecular biologist said after seeing heart cells beating in unison in a petri dish, she “can really imagine building a personalized human heart.”
Doris Taylor, director of regenerative medicine research at the Texas Heart Institute, said that by using a patient’s own tissue, they were able to create a viable option using pig cells that the body will not reject.
“It actually changed my life,” Taylor told CNN. “I said to myself, ‘Oh my god, that’s life.’ I wanted to figure out the how and why and recreate it to save lives.”
Taylor said the innovative replacement could become more of a planned procedure than last-minute surgery.
“That reduces your risk by eliminating the need for (anti-rejection) drugs, by using your own cells to build that heart, it reduces costs… and you don’t have to go to the hospital as often, which affects your quality of life.” improved.”
Taylor also presented a robot that was taught to administer the human stem cells into the ghost heart in a sterile environment.
The biologist showed video of the translucent manufactured heart, which turned pink after the injection.
“It is the first attempt to truly cure the world’s leading killer of men, women and children – heart disease. And then I want to make them accessible to everyone,” the scientist shared excitedly.
Advanced Solution’s CEO, Michael Golway, praised Taylor’s work and persistence throughout the year-long project.
“Dr. Taylor could easily have said at any time, ‘I’m done, this just isn’t going to work,'” Golway told CNN.
“But she’s fought doggedly and fought back for years to find the right cell type, in the right amount, and in the right conditions for those cells to be happy and grow.”
Taylor first became interested in growing hearts while working on a team at Duke University in 1998.
The team injected cells into a rabbit’s failing heart and created a new heart muscle.
However, whenever she tried to transfer success to human biology, it was success or failure.
“We introduced cells into damaged or scarred regions of the heart in the hope that this would overcome the existing damage,” Taylor said.
“I started thinking: What if we could get rid of this bad environment and rebuild the house?”
In 2008, Taylor found great success when she and the University of Minnesota team stripped a rat’s heart of cells and began working with the translucent skeleton left behind.
After this breakthrough, it moved into pig hearts because of its anatomical resemblance to humans.
“I just feel honored and privileged to do this work and proud of where we are,” said Taylor.
“The technology is ready. I hope everyone rides with us because this is groundbreaking.”
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https://www.the-sun.com/health/5480579/ghost-heart-grown-pig-organ-human-transplant/ “Ghost Heart” grown using a scaffold made from a PIG ORGAN and a patient’s own cells could soon be used in human transplants