Doctors amazed as drug in trial cures ‘every patient’ of colon cancer

DOCTORS shocked after experimental drug ‘cured’ colon cancer patients

They said the tumors “disappeared” after six months of treatment, with results “never seen before”.

The images above show how the tumors in two patients were cleared after the drug study. Left to right. How the tumors looked on endoscopies, MRIs, and PET scans before they started the drug. The middle images show the change three months later, with the end images showing hardly any tumors at six months

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The images above show how the tumors in two patients were cleared after the drug study. Left to right. How the tumors looked on endoscopies, MRIs, and PET scans before they started the drug. The middle images show the change three months later, with the end images showing hardly any tumors at six monthsPhoto credit: New England Medical Journal

Patients cried “happy tears” after the results, which scientists described as “unexpected.”

However, the study was only conducted on 12 patients in the US, and more research is needed before it is considered a standard of care.

Every participant who took the drug called dostarlimab went into remission with no signs of the disease in their bodies.

Doctors couldn’t find any signs of her colon cancer, also known as colon cancer.

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dr Andrea Cercek, an oncologist at Memorial Sloan Kettering Cancer Center and co-author of the study, told CNN, “It’s absolutely incredible.

“We didn’t expect that. We’ve certainly never seen this before.

“It really is what cancer doctors dreams are made of, to see a reaction like this… Such incredible efficacy with really almost no toxicity.”

She told the New York Times: “There were a lot of tears of joy.

“Particularly in patients where standard care would compromise childbearing potential.

“It’s incredibly rewarding to get those tears of joy and happy emails from the patients in this study who complete treatment and say, ‘Oh my god, I’m able to keep all of my normal bodily functions that I feared I wouldn’t they could lose through radiation or surgery’. “

The research paper, published in the New England Journal of Medicine (NEJM), said the impact on quality of life was “significant.”

co-author dr. Luis Alberto Diaz added that he believes this is the first time a drug has had this effect in the history of cancer.

The treatment applies to patients with rectal cancer (a type of colorectal cancer) who had mismatch repair deficiency (MMRd) or microsatellite instability (MSI) tumours.

Experts assume that these tumors make up about five to ten percent of all patients with rectal cancer.

All patients had received prior treatments such as chemotherapy.

Colorectal cancer is one of the deadliest cancers, being the fourth most common in the UK.

Around 43,000 people are diagnosed with the disease each year, with 268,000 Brits living with the disease.

Patients in the study received 500 milligrams of dostarlimab every three weeks for six months.

Originally, it was expected that the patients would need further treatments such as chemotherapy or radiotherapy.

However, the results showed that all of the patients’ cancers cleared with the drug alone.

The scans no longer showed any tumors and a year later no more patients needed treatment.

The Signs of Colon Cancer You Need to Know – Think COLON

  1. B: bleeding

There are several possible causes of bleeding from your butt or blood in your poop.

Bright red blood can come from swollen blood vessels, hemorrhoids, or hemorrhoids in your anus.

Dark red or black blood may come from your intestines or stomach.

Blood in the stool is one of the main signs of colon cancer, so it’s important to tell your doctor so he can investigate.

2. O: Obvious change in toilet habits

It’s important to let your GP know if you notice changes in your bowel habits that last three weeks or more.

It’s especially important if you’ve also noticed signs of blood in your poop.

You may find that you need to go to the bathroom more often, you may have looser stools, or you may feel like you are not walking enough or not emptying your bowels completely.

Don’t be embarrassed, your family doctor will have heard a lot worse! Speak up and have it checked.

3. W: weight loss

This is less common than the other symptoms, but it’s important to be aware of. If you have lost weight and do not know exactly why, you should tell your family doctor.

You may not feel like eating, feel sick, bloated and not hungry.

4. E: Extreme fatigue

Colon cancer that causes bleeding can cause iron deficiency in the body – anemia. If you develop anemia, you are likely to feel tired and your skin may look pale.

5. L: Lump or pain

As with many other types of cancer, lumps or pain can be a sign of colon cancer.

It is very likely that you will feel a pain or lump in your stomach or back passage

It has now been two years since the first study and none of the 12 patients required further treatment.

The drugs are believed to help shrink or eliminate patients’ tumors.

It unmasks hidden cancer cells, which then help the immune system find and destroy them.

As a result of the drug, patients did not have to undergo strenuous treatments – which means their quality of life improved as well.

There were few side effects, only 20 percent suffered from them – which medics said was easily manageable.

One patient experienced rectal bleeding but had no other symptoms.

Other experts have also praised the treatment, which costs around £9,000 a dose.

dr Hanna Sanoff, oncologist at the University of North Carolina’s Lineberger Comprehensive Cancer Center, said, “These results give cause for great optimism.

“But without further research, dostarlimab cannot yet replace the curative standard of care for rectal cancer with misfit repair.”

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https://www.the-sun.com/health/5505500/doctors-astounded-drug-cures-bowel-cancer-trial/ Doctors amazed as drug in trial cures ‘every patient’ of colon cancer

Sarah Y. Kim

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