A hunger-blocking drug could revolutionize the treatment of obesity

Men with an extra 10 cm at the waist are 7% more likely to die from prostate cancer

A new drug could bring a breakthrough in the fight against obesity (Credits: Getty)

A new drug could help obese people lose up to 24kg – nearly four stone – according to a big new study.

The drug, called Tirzepatid, is a weekly injection that targets a hormone called ghrelin, which regulates our appetite.

By drastically reducing food cravings, the drug (originally developed to fight diabetes) reduces the amount of calories a person consumes.

It is being developed by US pharmaceutical giant Lilly and could revolutionize the treatment of obesity.

According to a study published in the New England Journal of Medicine, people injected with the drug lost 22.5 percent of their body weight (on average) on a weekly basis. However, side effects such as diarrhea and vomiting have been noted.

Over 2,500 people from nine countries took part in the double-blind, randomized study. With an average weight of 105 kg (230 pounds), the volunteers were assigned to give themselves injections of low (5 mg), medium (10 mg) or high (15 mg) doses – or a placebo.

The results lasted 72 weeks and showed that the most effective dose of the drug was the highest.

“Tirzepatide is the first investigational drug to achieve an average of more than 20 percent weight loss in a Phase 3 study, which reinforces our confidence in its potential to help people living with obesity,” said Jeff Emmick, MD, PhD and Vice President of Product Development at Lilly.

Of course, the higher the dose, the worse the side effects. In addition to diarrhea and vomiting, participants reported nausea and constipation.

However, unlike bariatric surgery, which permanently changes a person’s eating habits, taking a weight loss drug can be stopped at any time.

“Obesity is a chronic disease that, despite its impact on physical, mental and metabolic health, which can include an increased risk of hypertension, heart disease, cancer and reduced survival, often does not receive the same standard of care as other conditions,” said Dr Louis J. Aronne, an obesity expert.

Lilly hopes the drug will come to market in the next few years, but says more testing needs to be done to determine if this drug is also useful for preventing type 2 diabetes.

obesity in the UK

According to the World Health Organization, obesity has almost tripled worldwide since 1975.

It remains a problem in the UK, where there were just over a million hospital admissions in which obesity played a role in 2021, according to NHS reports.

EMBARGOED TO 2301 TUESDAY MAY 3 File photo dated 28/07/10 of an overweight man. The majority of overweight people trying to lose weight are unsuccessful, a new study suggests. Just over a quarter of people with obesity who tried to lose weight managed to lose a significant amount a year later. Issue date: Tuesday May 3, 2022. PA Photo. The new study, which will be presented to the European Congress on Obesity in the Netherlands, looked at data from adults from the UK, France, Germany, Italy and Spain. Researchers led by Dr. Marc Evans of Cardiff University Hospital examined information from 1,850 obese adults with an average age of 53, of whom 79% said they had tried to lose weight in the past year. See PA story HEALTH Obesity WeightLoss. Photo credit should read: Dominic Lipinski/PA Wire

Obesity is on the rise in the UK, health officials say (Credits: PA)

Currently 64% of adults are overweight or obese, but the numbers are increasing every year.

According to an analysis by Cancer Research, this will rise even further to seven in ten (71%) within two decades.

Of these, 21 million people will be obese, which equates to four in 10 (36%) of all adults.

MORE : Calorie labels on alcohol? The study claims it could halt the rise in obesity in the UK

MORE: Jamie Oliver jokes about ‘government misconduct’ after Boris Johnson missed his anti-obesity U-turn protest to visit honey factory

https://metro.co.uk/2022/06/06/hunger-blocking-drug-could-revolutionise-obesity-treatment-16777959/ A hunger-blocking drug could revolutionize the treatment of obesity

Justin Scacco

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